Genotype - phenotype - environment interactions module

by Kees van Bochove — last modified Jan 26, 2011 04:44 PM
Here one can find information and data pertaining to metabolic syndrome-relevant gene-environment interactions within the genetics module of the Nutritional Phenotype Database. This includes access to a curated data table of published gene-environment interactions, as described by Lee, Parnell, et al. (2011) J Data Mining Genomics Proteomics (in press).

Description of the curation initiative at the JM-USDA HNRCA and Tufts Univeristy:

 

In order to facilitate the use of gene-environment (GxE) interactions into single-gene and genome-wide association studies, we have assembled from the literature and built a database of GxE interactions pertinent to nutrition, blood lipids, cardiovascular disease, type 2 diabetes, stroke/hypertension, dyslipidemia and obesity. Over 550 such interactions have been placed into one data table, along with more than 1430 examples where the test for interaction failed to reach statistical significance. This database is an important resource to researchers in genetics and nutrition so that they can gain an understanding of which loci in the human genome are sensitive to variations in diet, physical activity and alcohol and tobacco use, as well as other lifestyle choices. In addition, this GxE data table has been designed so that it may be integrated into the genetics module of dbNP.

 

Data table: Table 1 from Lee, et al (2011) is downloadable here (or use the direct download link).
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